Efficacy of pregabalin for refractory radicular leg pain arising from lumbar spinal stenosis

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Efficacy of pregabalin for refractory radicular leg pain arising from lumbar spinal stenosis

In this prospective observational study, the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) was probed. Total 104 LSS patients with neuropathic pain (NeP) in leg and neurological intermittent claudication (IMC) refractory to nonsteroidal anti-inflammatory drugs (NSAIDs) were considered for at least a month.

The Pain DETECT questionnaire screening tool was used to identify NeP. Before and 6 weeks after PGB treatment initiation, the Visual analog scale (VAS) scores and responses to the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were appraised. The changes in adverse events and IMC distance were also noted. VAS scores for pain and sleep quality (P < 0.001) was significantly ameliorated by PGB. Remarkable improvements were drawn out from the JOABPEQ results in the areas, such as: lumbar spine dysfunction (P < 0.031), pain-related disorders (P < 0.01), psychological disorders (P < 0.014) and gait disturbance (P < 0.028). After PGB treatment, IMC distance revealed an advanced tendency, though with no significance (P < 0.063). Minor adverse events like dizziness were noticed.

Thus, in  LSS patients, PGB can be effective for neuropathic leg pain refractory to NSAIDs leading to not only pain control but also improving lower back pain-related ADL/QOL values.

Pain Research and Management

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