Efficacy of glucosamine-containing supplement for subjects with knee pain
The effectiveness of glucosamine-containing supplementation for enhancing locomotor functions mainly walking speed have been revealed in previous studies. But, the biomechanical mechanism of efficacy has not been unraveled before. This pilot study of gait analysis focused on addressing this challenge in people with knee pain, using a motion capture system.
A study was carried out in 30 Japanese subjects with knee pain. These subjects were given a daily supplement containing 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, 1 mg of proteoglycan, and 5 µg of vitamin D (GCQID). The intervention continued for 16 weeks. The Japanese Knee Osteoarthritis Measure (JKOM) and the 5-question Geriatric Locomotive Function Scale (GLFS-5) was primarily used to evaluate the efficacy for locomotor functions involving the knee joint.
To determine the biomechanical mechanism of efficacy for locomotor functions, motions of subjects in a normal walking state were captured. Gait analysis was conducted and efficacy for gait parameters like normal walking speed, stride length, cadence, and angle of soles were investigated. GCQID remarkably improved total scores on the JKOM and GLFS-5. Stride length, normal walking speed and angle of soles at the end of the stance phase in the gait analysis notably increased, but cadence did not change significantly in the intervention period. Significant correlations of changes were observed in normal walking speed, stride length, and angle of soles at the climax of the stance phase, and between changes in stride length and total JKOM score.
It can thus be concluded that GCQID supplement may increase walking speed through increased stride length and angle of kicking from the ground during steps, which might be mainly related to attenuated knee pain.