Efficacy and Safety of Different Aceclofenac Treatments for Chronic Low Back Pain

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Efficacy and Safety of Different Aceclofenac Treatments for Chronic Low Back Pain
Key Take-Away: 

Aceclofenac can offer symptomatic pain relief, improvement in the quality of life and functional scores in patients with chronic low back pain. 

A condition across the, which are the mainstay of medical treatment in CLBP.

ABSTRACT: 
Background: 

A condition across the, which are the mainstay of medical treatment in CLBP. Increased dose intervals for medication have been associated with improved patient adherence to prescriptions.

The purpose of the presented clinical trial was to compare the efficacy and safety of a once-daily dose of aceclofenac controlled release (CR) and a twice-daily dose of aceclofenac for CLBP management.

Methods: 

A prospective, randomized, single center, an open-label clinical trial was performed to compare the efficacy and safety of aceclofenac CR (200 mg once daily) to aceclofenac dose (100 mg twice daily).

Fifty patients in each group were enrolled for the study. The primary endpoint was Visual Analogue Scale (VAS) change at baseline to that at two weeks after medication and safety profiles. Also, change in the quality of life measured by EuroQoL 5D (EQ-5D) and Oswestry Disability Index (ODI) functional score for the lumbar spine were also assessed.

Results: 

Within groups at pre- and post-treatment, there were significant VAS reductions for aceclofenac CR and aceclofenac (p=0.028).

EQ-5D increased significantly in both groups (p=0.037). ODI scores decreased significantly in both groups (p=0.012). However, there were no significant differences between aceclofenac CR and aceclofenac at pre- and post-treatment. Patients with aceclofenac CR showed significant increases in heartburn and indigestion and adverse gastrointestinal effects, compared to aceclofenac.

Conclusion: 

In patients with CLBP, aceclofenac CR and aceclofenac demonstrated significant symptomatic pain relief, improvement in the quality of life and functional scores.

Aceclofenac CR slightly increased gastrointestinal adverse effects, such as heartburn and indigestion.

Source:

Yonsei Medical Journal (YMJ)

Link to the source:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368152

The original title of the article:

Efficacy and Safety of Different Aceclofenac Treatments for Chronic Lower Back Pain: Prospective, Randomized, Single Center, Open-Label Clinical Trials

Authors:

Jae-Ho Yang et al.

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