Efficacy and Safety Of 0.75% Ropivacaine Instillation into Subinguinal Wound in Patients after Bilateral Microsurgical Varicocelectomy

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Efficacy and Safety Of 0.75% Ropivacaine Instillation into Subinguinal Wound in Patients after Bilateral Microsurgical Varicocelectomy
Key Take-Away: 

Ropivacaine is a long-acting amide local anesthetic. This anesthesia causes a sustain sensory or motor blockade by inhibiting nerve impulses, which is very beneficial for various surgeries. The trial enlightened that ropivacaine's could be helpful in minimizing pain after bilateral microsurgical varicocelectomy.

The aim of the study was to evaluate the efficacy and safety of 0.75% ropivacaine instillation into an inguinal wound in patients who have undergone bilateral microsurgical varicocelectomy.

ABSTRACT: 
Background: 

The aim of the study was to evaluate the efficacy and safety of 0.75% ropivacaine instillation into an inguinal wound in patients who have undergone bilateral microsurgical varicocelectomy.

Methods: 

Eighty-five men who were screened for bilateral varicoceles from March 2015 to July 2016 were randomized for the treatment. All patients underwent inguinal varicocelectomy by general anesthesia.

After ligation of the internal spermatic veins from the spermatic cord, additional delivery of testis through inguinal incision site was done to ligate external spermatic veins and gubernacular veins. Before repairing external oblique aponeurosis, 6 mL of 0.75% ropivacaine and 6 mL of normal saline were instilled under the fascia and around the funiculus (spermatic cord) by a randomized and double-blind method. Visual analog scale (VAS) pain score and Prince Henry Pain Score (PHPS) were used for evaluating operative sites at 1, 2, 4, and 8 hours and 7 days after surgery. Safety and tolerability were evaluated throughout the course of this study by assessing adverse events.

Results: 

A total of 55 men completed the study. Of these 55 men, 31 received instillation of ropivacaine on the left operative site, while 24 received instillation of ropivacaine on the right operative site.

VAS pain scores and PHPS in the ropivacaine-instilled operative site were significantly lower compared to those obtained with placebo at 2, 4, and 8 hours after surgery. In general, instillation of ropivacaine was safe and well tolerated in patients.

 

Conclusion: 

Ropivacaine instillation into subinguinal surgical site wound significantly reduced postoperative pain after microsurgical varicocelectomy.

 

Source:

Dove press

Link to the source:

https://www.dovepress.com/efficacy-and-safety-of-075-ropivacaine-instillation-into-subinguinal-w-peer-reviewed-article-JPR

The original title of the article:

Efficacy and safety of 0.75% ropivacaine instillation into subinguinal wound in patients after bilateral microsurgical varicocelectomy: a bi-center, randomized, double-blind, placebo-controlled trial

Authors:

Cui WS et al.

Therapeutic, Ropivacaine, Varicocele, Pain, Local Anesthesia, Bi-Center, Randomized, Double-Blind, Placebo-Controlled Trial, Efficacy, Safety, Tolerability, VAS, PHPS
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