Efficacy of Abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands

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Efficacy of Abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands
Key Take-Away: 

Abatacept is costimulation modulator used for the management of RA. In this study, the MRI of bilateral hands affirmed that Abatacept reduced synovitis and osteitis scores among RA patients and did not worsen erosion and JSN scores, but erosion started to repair in 10% of patients.

Introduction:

To investigate the efficacy of Abatacept among patients with rheumatoid arthritis (RA) applying magnetic resonance imaging (MRI) of bilateral hands.

 

Method:

A total of 35 RA patients selected for the analysis. MRI of bilateral hands was conducted at baseline and following 12 months of treatment with intravenous Abatacept. In accordance with RA MRI Scoring System (RAMRIS), MRI images for joint space narrowing (JSN), osteitis, synovitis, and erosion were obtained. Change in RAMRIS score from baseline was taken as the primary outcome. The repair of erosion was determined as a negative change in the erosion score which was larger than the smallest detectable changes (SDCs)

 

Results:

Thirty-one participants completed the analysis. Median synovitis and osteitis scores exhibited statistically notable declines at Month 12 as compared to baseline. Although, median erosion and JSN scores did not change. After one year, 83% of participants exhibited no improvement in erosion scores. Further, the repair of erosion was seen in 11% of the participants. Functional remission was observed in all the patients with repair of erosion. The independent factor prognosticating changes in the erosion scores at one year was the Simplified Disease Activity Index response rate at month one.

 

Conclusion:

Abatacept treatment decreased synovitis and osteitis scores and did not aggravate erosion and JSN scores at one year. Repair of erosion was experienced by over 10% of the participants.

Source:

Int J Rheum Dis. 2017 Jul 21.

Link to the source:

https://www.ncbi.nlm.nih.gov/pubmed/28730687

Original title of article:

Efficacy of Abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands.

Authors:

Kukida Y et al.

Therapeutic, Abatacept, Rheumatoid arthritis, Chronic, DMARDs, Prospective study, Symptomatic Therapy, Efficacy, RAMRIS score
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