Effects of Vitamin D on Endometriosis-Related Pain

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Effects of Vitamin D on Endometriosis-Related Pain

It has been noticed that oxidative stress caused by reactive oxygen species (ROS) also contributes to the endometriosis. Some of the vitamins have anti-oxidant properties which helps to reduces the oxidative stress. Endometriosis is a disabling disease of women of reproductive age and is characterized by dysmenorrhea, dyspareunia and pelvic pain. Endometriosis can be due to various causes which also includes vitamin D deficiency.

Almassinokiani F et al conducted a randomized double-blind clinical trial to diagnose the effects of vitamin D on Endometriosis. Patients were enrolled and diagnosed with the endometriosis. Patients were treated with the laproscopic technique and observed scores were at least 3 of dysmenorrhea and pelvic pain at 8 weeks after the surgical treatment. Vitamin D or placebo were prescribed randomly and further severity of pain in the 2 groups was compared by the VAS test at the interval of 24 weeks after the surgical treatment.

Total 19 and 20 patients were included in the vitamin D and the placebo group, respectively. Observed baseline characteristics in both groups were similar. However, no significant differences were noticed in the severity of pelvic pain and dysmenorrhea. After the laproscopic treatment in the vitamin D group, the mean pelvic pain scores were 0.84±1.74 while in placebo group it was 0.68±1.70 (p=0.513). Hence, after the ablative surgery for endometriosis, vitamind D treatment was not able to show any significant effect in reducing the dysmenorrhea and pelvic pain.


Med Sci Monit. 2016 Dec 17;22:4960-4966.

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Original title of article:

Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial.


Almassinokiani F, Khodaverdi S, Solaymani-Dodaran M, Akbari P, Pazouki A

Med Sci Monit. 2016 Dec 17;22:4960-4966.
Exploratory, Vitamin D, Endometriosis, Uterus, Double-blind Clinical Trial, VAS
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