The effects of oral Pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial

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The effects of oral Pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial
Key Take-Away: 

Hernia restoration is a general surgical approach with little postoperative complications, but some of the patients continue to tolerate chronic postoperative pain and discomfort for several months to years. As many of the studies govern the role of Pregabalin in post-surgical pain management, this analysis evaluates this drug efficacy and safety in managing post-Lichtenstein herniorrhaphy pain.
 

A gamma-aminobutyric acid analog, pregabalin shows excellent efficacy in maintaining different neuropathic pains, as well as in inflammatory and incisional injuries.

ABSTRACT: 
Background: 

A gamma-aminobutyric acid analog, pregabalin shows excellent efficacy in maintaining different neuropathic pains, as well as in inflammatory and incisional injuries.

A gamma-aminobutyric acid analog, pregabalin shows excellent efficacy in maintaining different neuropathic pains, as well as in inflammatory and incisional injuries. This study assessed the safety and effectiveness of Pregabalin on post-herniorrhaphy pain relief.

Methods: 

A total of 60 men were included in this randomized clinical trial for unilateral inguinal herniorrhaphy under spinal anaesthesia. The participants were randomly classified into two groups.

First is the investigation (Pregabalin) group obtained 300 mg of oral Pregabalin 2 h before and 150 mg of Pregabalin 12 and 24 h after surgery along with regular postoperative medicine and 1 mg/kg of pethidine as required. Second is the control (placebo) group underwent placebo capsules comparable to the investigation group, as well as regular medicine and 1 mg/kg of pethidine as wanted. The same technique was used to done all surgeries. The VAS (visual analog scale) at 12 h, 24 h, 3 and 7 days postoperatively used to determine post-surgery pain in lying and walking positions. The Pregabalin adverse effects and pethidine consumption were also evaluated.

Results: 

The VAS scores and pain at 12h, 24h and 3 days after treatment were lowered in the investigational group.

The participants in the investigational group also consumed less pethidine (p<0.05).
 

Conclusion: 

Pregabalin decreases the opioid intake and pain in the first 3 days after the operation. The adverse effects of Pregabalin are confined to the initial 12 h after the treatment. Pregabalin can be recommended for pain alleviation, but in the elders should be used with caution.

Source:

J Basic Clin Physiol Pharmacol

Link to the source:

https://www.degruyter.com/view/j/jbcpp.2018.29.issue-4/jbcpp-2016-0196/jbcpp-2016-0196.xml

Original title of article:

The effects of oral Pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial

Authors:

Mohammad Hossein Moghimi et al.

Therapeutic, Pregabalin, Postoperative Pain, Anticonvulsant, Randomized Clinical Trial, Efficacy, VAS
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