Effects of Omega-3 Fatty Acids on the Frequency, Severity, and Duration of Migraine Attacks

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SCIENCE
Effects of Omega-3 Fatty Acids on the Frequency, Severity, and Duration of Migraine Attacks
Key Take-Away: 

It was demonstrated that dietary interventions with omega-3 fatty acids potentially benefit the migraine patients in terms of the duration of attacks.

Migraine is the third most common disease in the world with an estimated global prevalence of 14.7%. Omega-3 fatty acids are categorized under essential polyunsaturated fatty acids (PUFAs). 

ABSTRACT: 
Background: 

Migraine is the third most common disease in the world with an estimated global prevalence of 14.7%. Omega-3 fatty acids are categorized under essential polyunsaturated fatty acids (PUFAs).

Its neuroprotective and inflammatory properties might be valuable to reduce migraine frequency and the duration of attacks. The present systematic review with meta-analysis of randomized controlled trials (RCTs) aimed to analyze the effectiveness of omega-3 fatty acids on the frequency, severity, and duration of migraine.

Methods: 

This systematic review was performed by searching several databases for controlled clinical trials. Of the thirteen trials, five, two, and three RCTs met the eligibility criteria to evaluate the efficacy of omega-3 fatty acid on the frequency, duration, and severity of migraine attacks, respectively.

The Jadad scale was used to evaluate the risk of bias analysis. Overall estimates of the intervention effect were obtained from the random-effect meta-analysis. The studies’ heterogeneity was evaluated using the chi-squared test (χ2) (Cochran’s test (Q test)) and I2 Index. Potential sources of heterogeneity among the trials were investigated by meta-regression analyses.

Results: 

The results showed that omega-3 fatty acid intake had no effect on frequency

(WMD = −0.20; 95%CI −0.67, 0.27; P = 0.401, and I2 = 4.6%; P = 0.380) and severity (SMD = −0.59; 95%CI −1.85, 0.66; P = 0.35, and I2 = 88.8%; P = 0.000) of migraine, but had a reduction effect on the duration of migraine attacks (WMD = −3.44; 95%CI −5.70, −1.19; P = 0.003, and I2 = 0.0%; P = 0.926).

Conclusion: 

In conclusion, omega-3 fatty acid intake leads to a significant reduction of approximately 3.44 hours in the duration of migraine. Further RCTs of high methodological quality with adequate sample sizes are required to confirm the results of the meta-analyses.

 

Source:

Nutr Neurosci. 2017 Jun 30:1-10

Link to the source:

https://www.ncbi.nlm.nih.gov/pubmed/28665211

The original title of the article:

Effects of omega-3 fatty acids on the frequency, severity, and duration of migraine attacks: A systematic review and meta-analysis of randomized controlled trials

Authors:

Maghsoumi-Norouzabad L et al.

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