Effectiveness and Safety of Zoledronic Acid in the Treatment of Osteoporosis

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SCIENCE
Effectiveness and Safety of Zoledronic Acid in the Treatment of Osteoporosis
Key Take-Away: 

Zoledronic acid or zoledronate (ZA) is a bisphosphonate drug which is given intravenously to treat some bone diseases. This study provides valuable insights into the use of ZA in real-world settings. This treatment with once-yearly dosing of ZA improves adherence and clinical outcomes in patients with osteoporosis.

The effectiveness of current treatments for osteoporosis is limited by poor patient compliance.

ABSTRACT: 
Background: 

The effectiveness of current treatments for osteoporosis is limited by poor patient compliance.

However, a favorable dosing regimen of zoledronic acid (ZA) has the potential to improve patient compliance and thus clinical outcomes.

Methods: 

The author conducted a retrospective analysis to examine adherence to and the antiosteoporotic effects of a once-yearly infusion of 5 mg of ZA in Taiwanese patients with osteoporosis for up to 48 months.

Five men and 149 postmenopausal women (mean age, 77.1 years) were included. Prior to ZA treatment, 66.2% of patients had fractures; most patients discontinued previous treatments due to compliance or convenience issues. Approximately 85% of patients received at least 2 infusions of ZA.

Results: 

Following ZA treatment, bone mineral density improved from baseline at 12 months (11% from baseline; P=.01) and 48 months (20.7% from baseline; P=.009).

In addition, there was a significant reduction in mean beta-C-telopeptide at all-time points from 12 (P<.001) to 36 months (P=.010). New clinical fractures occurred in 16 (10.4%) patients, of which 12 patients experienced a single fracture. Zoledronic acid had an acceptable safety profile; no adverse events were considered to be drug related. Treatment with ZA improved bone health by enhancing bone mineral density and reducing bone turnover, even in high-risk patients.

Conclusion: 

Low fracture rates and high adherence further elucidate the benefits of ZA in the treatment of osteoporosis.

Orthopedics 2016 Mar 1;39(2): e263-70

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