DRUG TARGETS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

Primary tabs

Education
DRUG TARGETS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with an estimated prevalence of 0.5-1% of the population worldwide; it is also reported that women are more affected than men are. [1]. RA is characterized by joint inflammation,
synovial proliferation and destruction of articular cartilage. Immune complexes composed of IgM activate complement and release cytokines (mainly TNFα and IL-1) which are chemotactic for neutrophils. These inflammatory cells secrete lysosomal enzymes, which damage cartilage and erode bone, while PGs produced in the process cause vasodilatation and pain.

Therapeutiv, NSAIDs, Rheumatoid arthritis, Drug targets
Log in or register to post comments