Drotaverine Hydrochloride (80 mg) and Paracetamol (500 mg) Combination to ease Abdominal Pain

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Drotaverine Hydrochloride (80 mg) and Paracetamol (500 mg) Combination to ease Abdominal Pain

A recently published study in 'Journal of Gastroenterology and Hepatology' deduced that a fixed dose combination of Drotaverine hydrochloride (80 mg) and Paracetamol (500 mg) is an effective and safe antispasmodic agent for abdominal pain due to acute infectious gastroenteritis.

Acute gastroenteritis is defined as inflammation and/or irritation of the digestive tract that can cause nausea, vomiting, diarrhoea, and abdominal pain that lasts for >14 days. A randomized trial was executed by Narang S and Koli J to investigate the efficacy and safety of a fixed dose combination of Drotaverine hydrochloride 80mg and Paracetamol 500mg. To solve the purpose of the study, a comparison of mean pain intensity difference (mPID), total pain relief at 2 hours (TOTPAR2), onset of pain relief, decrease in the number of pain episodes, global improvement and adverse effects was done.

A total of 252 (126 in each group) participants aged between 18-59 years of either gender were included in this randomized double blind controlled trial. They experienced acute infectious diarrhoea (≥3 unformed, watery or soft, stools with symptoms at-least within last 24 hours prior randomization with duration of illness, not more than 72 hours) with moderate to severe abdominal pain. For 3 days, the participants were treated with either a fixed dose combination of oral Drotaverine hydrochloride 80 mg and Paracetamol 500 mg or just oral Paracetamol 500 mg three times daily/ t.i.d. The study was completed by 242 participants. Statistically significant improvement in Drotaverine hydrochloride 80 mg and Paracetamol 500 mg group via mean pain intensity difference (mPID) at 60 minutes after administration of study medication by Visual Analogue Scale (VAS), TOTPAR 2 using both VAS and Verbal Rating Scale (VRS) was observed. The pain onset relief was also significantly better in Drotaverine hydrochloride 80 mg and Paracetamol 500 mg group when applying VAS.

Source

J Gastroenterol Hepatol. 2018 Jul 3.

Link to the source

https://www.ncbi.nlm.nih.gov/pubmed/29968385

Original title of the article

Efficacy and Safety of Fixed Dose Combination of Drotaverine Hydrochloride (80 mg) and Paracetamol (500 mg) in Amelioration of Abdominal Pain in Acute Infectious Gastroenteritis: A Randomized Controlled Trial

Authors

Narang S, Koli J

SearchTags: 
Therapeutic, Drotaverine Hydrochloride, Paracetamol, Abdominal Pain, Infectious Gastroenteritis, Abdomen, Acute, Phosphodiesterase 4 inhibitor, Antispasmodic, Analgesic, Randomized double blind controlled trail, Efficacy, Safety, Visual Analogue Scale (VAS), Total pain relief at 2 hours (TOTPAR 2), Verbal Rating Scale (VRS), Oral
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