Dexibuprofen

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DRUGS
Dexibuprofen

Dexibuprofen belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). Dexibuprofen is used to treat painful conditions such as arthritis, sprains and strains, period (menstrual) pain, and dental pain.

Introduction

Dexibuprofen belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). Dexibuprofen is used to treat painful conditions such as arthritis, sprains and strains, period (menstrual) pain, and dental pain.

Pharmacological class: NSAID

Indications

  • Dysmenorrhea

  • Osteoarthritis

  • Sprains

Pharamcological Action

Dexibuprofen works by blocking the effect of chemicals in the body, called cyclooxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called as prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

Dosage

The recommended adult dose is 600-900 mg/day in 2-3 divided doses, up to 1,200 mg/day in acute exacerbations.

Pharmacokinetics

Plasma protein binding is 99%. Renal Excretion accounts for 90% and plasma half-life is 1.8 to 3.5 hours.

Contraindications

  • Contraindicated in patients with history of bronchial asthma; renal or hepatic disorders

  • Contraindicated in patients with bleeding disorders

  • Contraindicated in patients with CV disease

  • Contraindicated in elderly patients

  • Contraindicated in pregnant and lactating mothers.

  • Contraindicated in patients with known hypersensitivity to aspirin or NSAIDs

Drug Interactions

  • Concomitant use with anticoagulants, other NSAIDs and salicylates may increase risk of kidney diseases.

  • Dexibuprofen may reduce removal of medicines like digoxin, lithium and methotrexate from body, thus may increase blood levels and risk of side effects of medicines

  • Dexibuprofen may oppose the blood pressure lowering effects of few medicines to treat high blood pressure (aliskiren), ACE inhibitors (captopril), angiotensin II antagonists (losartan), beta-blockers (atenolol) and calcium-channel blockers (amlodipine).

Side effects

Common (affecting between 1 in10 to 1 in 100)

  • Nausea

  • Vomiting

  • Abdominal pain

  • Lethargy

  • Headache

  • Rash

  • Diarrhea

  • Heart burn

Uncommon (affecting 1 in 100 to 1 in 1000)

  • Tinnitus

  • Dyspepsia

Very rare (affecting less than 1 in 10,000)

  • Ulceration

  • Stomach or intestinal bleeding

  • Jaundice

  • Hepatitis

Precautions

  • Caution should be exercised in patients with history of bronchial asthma, kidney or liver impairment, bleeding disorders, heart disease, elderly, and breastfeeding.

  • Do not drive or operate machinery while taking dexibuprofen, as it may cause dizziness.

  • Avoid consuming alcohol while taking it.

  • Stop taking it or consult doctor if you pass blood in your stools/motions, pass black tarry stools, vomit any blood.

Clinic Evidence

In the efficacy study 178 inpatients with osteoarthritis of the hip were assigned to 600 or 1200 mg of dexibuprofen or 2400 mg of racemic ibuprofen daily. The primary end-point was the improvement of WOMAC OA index. A 1-year open tolerability study included 223 outpatients pooled from 6 studies. The main parameter was the incidence of clinical adverse events. Evaluation of the improvement of WOMAC OA index showed equivalence of dexibuprofen 400 mg t.i.d. compared to racemic ibuprofen 800 mg t.i.d., with dexibuprofen being borderline superior (P = 0.055). The comparison between 400 mg t.i.d. and 200 mg t.i.d. doses confirmed a significant superior efficacy of dexibuprofen 400 mg (P = 0.023). The active enantiomer dexibuprofen proved to be an effective NSAID with a significant dose-response relationship. Compared to double dose of racemic ibuprofen, dexibuprofen was at least equally efficient, with borderline superiority over dexibuprofen (P = 0.055). The tolerability study in 223 patients on dexibuprofen showed clinical adverse events of 15.2% after 12 months. The results of the studies suggest that dexibuprofen is an effective NSAID with good tolerability.1

References

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