To develop local anaesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management

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To develop local anaesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management

Although local anaesthesia is commonly applied for pain relief, there are several issues such as its short duration of action and low effectiveness due to the acidic pH in the areas of inflammation. Reactive oxygen species in the excessive amount of (ROS) is common to induce pain and inflammation.

Developed ROS-scavenging activity with a redox-active injectable gel (RIG) to resolve these issues. RIG was prepared by mixing polyamine-b-poly(ethylene glycol)-b-polyamine with nitroxide moieties as side chains with a polyanion on the polyamine segments (PMNT-b-PEG-b-PMNT), which formed a flower-type micelle via electrostatic complexation. Lidocaine could be incorporated stably into the core. The PIC-type flower micelle transformed to gel by the increased temperature of the solution to 37° C. Lidocaine continuous release from the gel was observed for three days or more, remarkable without initial burst, most likely receivable to the stable entrapment of lidocaine in the PIC gel core. Assess the analgesic effect of RIG in carrageenan-induced arthritis mouse model. An assessment showed that lidocaine-loaded RIG has stronger and more prolonged analgesic effect in inflamed effected site. Non-complexed lidocaine administration did not perceive analgesic effect. It is noted that no effect was detected when PIC-type flower micelle was used without ROS-scavenging ability. Evaluated that showed local anaesthetic-loaded RIG could efficiently reduce the number of injection times and limit the side effects. It is associated with the use of anti-inflammatory drugs for postoperative pain management.

Source:

Acta Biomater. 2017 Jul 15;57:127-135

Link to the source:

https://www.ncbi.nlm.nih.gov/pubmed/28457963

Original title of the article:

Development of a local anesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management.

Authors:

Nagasaki Y. et. al.

SearchTags: 
Therapeutic, Lidocaine, Pain, Anesthetic, Research article, Efficacy, Safety
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