Delayed anti-TNF treatment increases the risk of total knee replacement in patients with severe rheumatoid arthritis

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Delayed anti-TNF treatment increases the risk of total knee replacement in patients with severe rheumatoid arthritis

Rheumatoid arthritis (RA) patients can have substantial long-term consequences. One 18-year longitudinal study published in 1998 determined that 25% of all patients with RA required total joint replacement surgery.
Severe rheumatoid arthritis study assesses the effect of early anti-tumour necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the successive risk of total knee replacement (TKR) surgery.

This retrospective experimental study involved a hospital-based cohort of 200 patients recognised with severe RA who received therapy with anti-TNF therapy between 2003 and 2014. Sex, age, BMI, and the time from the diagnosis of RA to the initiation of anti-TNF treatment were analysed.

84 patients underwent an early intervention (≤3 years from the diagnosis of RA to the initiation of anti-TNF treatment), and116 underwent a late intervention(>3 years from the diagnosis of RA to the commencement of anti-TNF treatment). Five (6.0%) patients in the prior intervention group underwent TKR differentiate to 31 (26.7%) in the late intervention group (p = 0.023). After modifying for confounding aspect, the late intervention group still had a consequently higher risk of TKR (p = 0.004; odds ratio, 5.572; 95% confidence interval, 1.933–16.062). Those undergo therapy involved methotrexate had lower chances of TKR (p = 0.004; odds ratio, 0.287; 95% confidence interval, 0.122–0.672).

Delayed commencement of anti-TNF therapy in the treatment of severe RA was related to an increased risk of TKR surgery. Adding methotrexate treatment reduced the risk of future TKR.

Source:

BMC Musculoskeletal Disorders

Link to the source:

https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-017-1685-z

Original title of the article:

Delayed anti-TNF therapy increases the risk of total knee replacement in patients with severe rheumatoid arthritis

Authors:

Ying-Chou; C. et al.

SearchTags: 
Therapeutic, Methotrexate, Rheumatoid arthritis, Total knee replacement, Knee, Severe, Anti-TNF, Retrospective
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