Comparison of two Ibuprofen Formulations in Patients with Acute Odontogenic Pain

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SCIENCE
Comparison of two Ibuprofen Formulations in Patients with Acute Odontogenic Pain
Key Take-Away: 

In this randomized study, a comparative analysis has been conducted between ibuprofen sodium dihydrate and conventional ibuprofen acid, and it has been determined that ibuprofen sodium dihydrate was more efficacious for pain relief than ibuprofen acid.

The main aspect of pain management lies in the understanding whether what you do to patients will or will not initiate an inflammatory response, which is what triggers the pain-producing mediators in tissue.

ABSTRACT: 
Background: 

The main aspect of pain management lies in understanding whether what you do to patients will or will not initiate an inflammatory response, which is what triggers the pain-producing mediators in tissue.

 In dentistry, odontogenic pain refers to pain initiating from the teeth or their assisting structures (the mucosa, gingivae, maxilla, mandible or periodontal membrane). Ibuprofen sodium dihydrate, a new formulation of ibuprofen, was introduced with the claim of the faster onset of analgesia. Most of the data on this new ibuprofen formulation is drawn from studies using the oral surgery model. Because this model differs significantly from the endodontic pain model, a study comparing ibuprofen sodium dihydrate with conventional ibuprofen acid in endodontic pain patients was conducted. 

Methods: 

A randomized, double-masked study by Taggar T et al., recruited patients experiencing moderate to severe pain from a tooth diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis (n=41).

Patients were randomized to receive 400 mg ibuprofen acid (Advil; Pfizer, Madison, NJ) or an equivalent dose of 512 mg ibuprofen sodium dihydrate (Advil Sodium, Pfizer). The outcome measures were time to onset of 50% pain relief recorded using a stopwatch, reduction in spontaneous pain experienced on a 100-mm visual analog scale (VAS), and change in mechanical allodynia measured using a bite force transducer. The last two measures were obtained before and 60 minutes after administration of the drug. 

Results: 

The median time to onset of 50% pain relief after administration of ibuprofen sodium dihydrate was significantly faster as compared with ibuprofen acid (26.5 vs 44 minutes, p=0.08).

Ibuprofen sodium dihydrate provided a greater reduction in spontaneous pain (50.8% vs 33.3%, p<0.05) and mechanical allodynia (15% vs 9%, p>0.05).

Conclusion: 

In endodontic pain patients, a single dose of ibuprofen sodium dihydrate provides faster onset of pain relief and a greater reduction in spontaneous and evoked pain as compared with ibuprofen acid.

Source:

Journal of Endodontics

Link to the source:

http://www.jendodon.com/article/S0099-2399(16)31063-9/pdf

The original title of the article:

A Randomized Clinical Trial Comparing 2 Ibuprofen Formulations in Patients with Acute Odontogenic Pain

Authors:

Tanjit Taggar et al.

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