A Comparative Study of the Transdermal Penetration of a Series of Non-steroidal Anti-inflammatory Drugs

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A Comparative Study of the Transdermal Penetration of a Series of Non-steroidal Anti-inflammatory Drugs

The transdermal absorption of a series of non-steroidal anti-inflammatory drugs (NSAIDs): indomethacin, ketoprofen, diclofenac, piroxicam, tenoxicam, ketorolac and aceclofenac were studied in vitro with human skin. The purpose of this study was to determine the penetration parameters (permeability rate constant Kp;lag time, Tl,and flux,J)), as measures of the intrinsic transdermal penetration of these drugs to predict their potential for formulation in a transdermal therapeutic system (TTS ).

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Journals of Pharmaceutical Sciences/503, Vol 86, No.4, April 1997
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