Comparative effect of cinnamon and ibuprofen for treatment of primary dysmenorrhea

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SCIENCE
Comparative effect of cinnamon and ibuprofen for treatment of primary dysmenorrhea
Key Take-Away: 
  • Cinnamon is not as effective as ibuprofen but can be used as a safe treatment for primary dysmenorrhea as it significantly reduces the severity and duration of pain.
  • The mean pain severity at 4 hours after treatment was less in cinnamon group than placebo group but was not statistically significant whereas at 8 hours after treatment, mean pain severity of cinnamon group was significantly lower than placebo group (p<.0.001). The mean pain severity of ibuprofen at all time intervals was less than control and cinnamon groups.

Primary Dysmenorrhea is a very common problem with females and its prevalence in diverse population is between 50% and 90%. It involves cyclic and painful cramps in the pelvic region just before or at the time of menstruation affecting day to day activities.

ABSTRACT: 
Background: 

Primary Dysmenorrhea is a very common problem with females and its prevalence in diverse population is between 50% and 90%. It involves cyclic and painful cramps in the pelvic region just before or at the time of menstruation affecting day to day activities.

Main treatments: NSAID, prostaglandin inhibitors, non pharmacological exercises, heat therapy, acupuncture, trans-electrical nerve simulation, dietary supplements and medicinal herbs

The chemical drugs may produce many side effects like stomach irritation, nausea, ulcers, decrease renal blood flow etc. Medicinal herbs may be used for the treatment of dysmenorrhea. Cinnamon Zeylancium is one of the popular spices and herb with much application in medicine.

 

Rationale behind research

  1. Cinnamon Zeylancium is known for its various biological properties
  2. Evidence of its application is not very well documented primarily for the treatment of dysmenorrhea
  • Objective

 To compare the effect of Cinnamon and Ibuprofen for the treatment of primary dysmenorrhea

Methods: 

 

Study outcomes

  • Severity of pain was measured using visual analog scale (VAS) of 0 to 10. Zero denoted no pain and 10 denoted most severe pain that patient had ever experienced
  • Duration of the pain was measured using Cox  Menstrual Scale

Time-points

  • Pain Severity
  • Efficacy: Baseline, 7 times day 1, day 2 and day 3
  • Side effects: Baseline, 7 times day 1, day 2 and day 3

Pain intensity: Monitored in the group during first 72 hours of cycle

Duration of pain: Assessed once daily

Results: 

     

    Baseline: Two treatment groups were well balanced with no statistically significant difference

    Outcomes

    • Mean pain severity score in Ibuprofen and Cinnamon group was less than placebo group at different intervals of time

     

    Figure 1: Pain Severity

    • Mean pain severity in cinnamon group at 4 hours after treatment was less than the placebo group but was not statistically significant whereas at 8 hours after treatment, mean pain severity of cinnamon group was significantly lower than placebo group (p<.0.001).
    • Mean pain severity of ibuprofen at all time intervals was less than control and cinnamon groups
    • Mean duration of pain in Ibuprofen and Cinnamon were significantly less than placebo group at various time intervals (p< 0.001)
    • Mean pain severity score in Ibuprofen and Cinnamon group was less than placebo group at different intervals of time

    Figure 2: Duration of Pain

    • No adverse events were reported
    Conclusion: 

    Conclusion: Result indicates that Cinnamon can be used as a safe treatment for primary dysmenorrhea as it significantly reduces severity and duration of pain.

    The results of this trial are consistent with previous study showing positive effect of herbal medicines like Cumin, Thymus Vulgaris, Achillea Millefolium, Fennel, Matricaria Recutita, Rosa Damascena extract and Zingiber Officinale in the treatment of dysmenorrhea. This study was performed with relatively smaller subject group hence more research with greater statistical population should be done to evaluate efficacy of cinnamon in primary dysmenorrhea.

    Journal of Clinical and Diagnostic Research 2015 Apr; 9(4):QC04-7

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