A combination of Famciclovir + Celecoxib - A is safe and effective for the treatment of fibromyalgia

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A combination of Famciclovir + Celecoxib - A is safe and effective for the treatment of fibromyalgia

The development of fibromyalgia has been implicated in infections and other stressors. These stressors could result in repeated reactivations of latent herpes virus infections, leading to the development of fibromyalgia. Pridgen WL et al. evaluated a new drug combination famciclovir and celecoxib (IMC-1) active against suspected herpes virus reactivation and infection, hence, used for cure of fibromyalgia.

A double-blinded, placebo-controlled proof-of-concept trial was conducted with 143 fibromyalgia patients enrolled at 12 sites in a 16-week. These randomized patients received either IMC-1 or placebo in a 1:1 ratio. The results were supported by parameters, 24-hour recall pain Numerical Rating Scale, the Revised Fibromyalgia Impact Questionnaire (FIQ-R), Patient’s Global Impression of Change (PGIC) questionnaire, Multidimensional Fatigue Inventory, NIH Patient-Reported Outcomes Measurement Information System (PROMIS) and the Beck Depression Inventory-II studied at baseline and 6, 12, 16 weeks.

The results indicated that there is a significant decrease in fibromyalgia-related pain in patients on IMC-1 treatment versus placebo. IMC-1 treatment significantly improved PGIC response rates. Patient self-reported functioning was measured by the FIQ-R and found to be improved. Fatigue was improved as measured by the PROMIS fatigue inventory. The safety profile was quite stimulating. Adverse events were reported less frequently in the IMC-1 group when Gastrointestinal and nervous system treatment was done despite the celecoxib component of IMC-1.

It was proved that IMC-1 was efficacious and safe in treating symptoms of fibromyalgia, which supports the hypothesis that herpes virus infections can also contribute to this syndrome. The safety and efficacy of the combination were suggested by improved retention rates, decreased adverse event rates and evidence of efficacy on a broad spectrum of outcome measures.

Source:

Dove press

Link to the source:

https://www.dovepress.com/a-famciclovir--celecoxib-combination-treatment-is-safe-and-efficacious-peer-reviewed-article-JPR

Original title of article:

A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia

Authors:

Pridgen WL et al.

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