Chronic Joint Pain and Hand Grip Strength Correlates with Osteoporosis in Mid-life Women

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Chronic Joint Pain and Hand Grip Strength Correlates with Osteoporosis in Mid-life Women
Key Take-Away: 

A novel screening tool constituting age, weight, post-menopausal status, chronic joint pain and handgrip strength has been investigated in this study for its potential to predict spinal osteoporosis in mid-life women.

Osteoporosis is common in midlife women and will increase as the population ages. It significantly decreases the quality of life with an increasing economic burden on health-care resources. The possibility of developing a prediction model for osteoporosis (OP) was explored which resulted in a risk assessment tool that performed better than currently available tools

ABSTRACT: 
Background: 

Osteoporosis is common in midlife women and will increase as the population ages. It significantly decreases the quality of life with an increasing economic burden on health-care resources.

The possibility of developing a prediction model for osteoporosis (OP) was explored which resulted in a risk assessment tool that performed better than currently available tools. To identify novel factors associated with low spinal bone mineral density (BMD) in mid-life women, the researchers examined a large number of lifestyle and medical and performance measurements and developed a prediction model for triage to BMD scanning.

Methods: 

Women (n=512) aged 45-69 years (mean 57.0±6.3) attending gynecology clinics for "well woman" visits were recruited for this cross-sectional study from 2014 to 2015.

All the participants were assessed for symptoms, medical history, anthropometry, and physical performance were assessed. Stepwise multinomial logistic regressions were performed to examine significantly associated covariates for pre-specified outcomes (normal [T-score ≥ -1.0], low bone mass [T-score between -1 and -2.5], and OP [T-score ≤ -2.5] at the lumbar spine). A new screening model was developed, and its performance was compared with the OP Screening Tool for Asians (OSTA) and Fracture Risk Assessment Tool (FRAX®).

Results: 

Spinal OP was reported in 6.8% of participants. Multivariate analysis indicated that chronic joint pain, the most common symptom reported by 37.5% of the women, was significantly associated with OP.

Only age (Relative Risk Ratio [RRR] 1.63; 95%CI, 1.03-2.60), weight (RRR 0.14; 95% CI, 0.07-0.27), postmenopausal status (RRR 11.59, 95%CI, 1.15-116.73), chronic joint pain (RRR, 4.12; 95% CI, 1.53-11.07), and right hand grip strength (RRR 0.50; 95% CI, 0.31-0.80) were independently associated with spinal OP. Combining these five variables, our final model's area under curve (AUC) was significantly higher at 84% than both the OSTA [AUC; 79% (p-value < 0.0231 'c' statistics)] and FRAX® [AUC 58% (p<0.0001 'c' statistic)].

Conclusion: 

A novel screening tool that combines age, weight and menopausal status with chronic joint pain and right-hand grip strength more reliably predicts spinal OP in mid-life Singaporean women.

 

Source:

Osteoporos Int. 2017 Jun 24.

Link to the source:

https://www.ncbi.nlm.nih.gov/pubmed/28647803

The original title of the article:

Chronic joint pain and hand grip strength correlates with osteoporosis in mid-life women: a Singaporean cohort

Authors:

Logan S et al

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