Cellular aging relation with pain sensitivity and sleep in women suffering from fibromyalgia

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Cellular aging relation with pain sensitivity and sleep in women suffering from fibromyalgia
Key Take-Away: 

Fibromyalgia is pain disorder associated with muscles and skeletal system that poses a major threat to the public. In this study, the relationship between cellular aging and sleep disturbances has been understood by actigraphy assessment and explained.

Fibromyalgia syndrome (FMS) is a common musculoskeletal pain disorder that presents a serious public health concern and imposes significant costs on society.

ABSTRACT: 
Background: 

Fibromyalgia syndrome (FMS) is a common musculoskeletal pain disorder that presents a serious public health concern and imposes significant costs on society. Sleep disturbance is ubiquitous in FMS and implicated as a potential mechanism for pain and related symptoms.

Recently, the degree of cellular aging has also been implicated in sleep disturbance and chronic pain.

Methods: 

In this study, we prospectively evaluated the relationship among sleep, pain sensitivity, and telomeric length (TL) in FMS women and healthy sedentary (HS) women.

A total of 23 FMS women and age matched 19 HS women were included. Each participant underwent a series of thermal ischemic pain testing, completed questionnaires, and had blood drawn at the laboratory. They also completed a 7-day home actigraphy assessment.

Results: 

Overall, FMS women exhibited significantly lower pain thresholds (p values<.05) and reported greater FMS-related symptoms (ps<.05) than did the HS women.

Relative to the HS women, FMS women reported greater sleep disturbance with self-report diary (ps<.05), but not with actigraphy sleep parameters. Telomeric lengths were comparable between the groups. There were significant correlations between TL and thermal pain threshold (ps<.05), with the longer TL associated with greater pain sensitivity. Actigraph WASO (wake after sleep onset) and total time in bed were also significantly associated with longer TL (p<.05). Separate correlation analyses showed differential associations between sleep and pain. For FMS women, greater ischemic pain tolerance was associated with greater WASO and poorer sleep efficiency whereas HS women showed that higher thermal threshold was associated with greater sleep efficiency and decreased WASO. 

Conclusion: 

Although preliminary, our data suggest that cellular aging may be uniquely related to pain sensitivity and sleep quality.

Source:

The Journal of Pain

Link to the source:

http://www.jpain.org/article/S1526-5900(17)30240-7/fulltext

Original title of article:

Sleep and pain sensitivity and its relationship to cellular aging in women with fibromyalgia

Authors:

 E. Iacob et al.

The Journal of Pain
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