The bone-cartilage crosstalk in Osteoarthritis

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The bone-cartilage crosstalk in Osteoarthritis

Osteoarthritis (OA) is regarded as a cartilage degradation disease of all tissues of the jointand may involve the degradation of complete joint . It is not merely a wear and tear process but an abnormal remodelling and joint failure of an organ. Particularly, the cartilage and subchondral bone interaction (crosstalk) is thought to be a key feature of this process. Thus, this bone cartilage interface is a functioning synergistic unit, with a close physical association between subchondral bone and cartilage indicating the existence of biochemical and molecular crosstalk across the OA interface. At the end of the respective long bones. lies the trabecular bone below the subchondral plate.

In osteoarthritis, there are well-described progressive destructive changes in the articular cartilage, which parallel characteristic changes in the latent bone.

The current review supported the of biochemical and biomechanical signaling between the tissue compartments in OA disease progression as a key role. Several questions are raised if such signaling might furnish possibilities for therapeutic intervention to halt or slow the development of the disease.

The increased understanding of crosstalk between the cartilage and bone in joints during OA will lead to emerge new treatments that hinder or protect the involved pathways. This identification can be done via targeting angiogenesis, neurogenesis and subchondral bone remodelling to reduce the molecular interaction.

 

Source:

Bone research

Link to the source:

http://www.nature.com/articles/boneres201628

Original title of article:

Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

Authors:

David M Findlay and Julia S Kuliwaba

 

Bone research
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