The association between psoriasis and psoriatic arthritis is revealed in a recent study

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The association between psoriasis and psoriatic arthritis is revealed in a recent study

Psoriatic arthritis (PsA) is common among patients suffering from psoriasis.  It is psoriasis (Ps) associated inflammatory joint disease which affects the peripheral joints, entheses, the spine and eyes.  Psoriatic arthritis evolves in about 70% of patients with psoriasis and is characterized by bone erosion and bone formation. The pathogenesis of PsA and Ps encompasses both the innate and adaptive immunity and the trauma may be a possible trigger for both these conditions.

As per the reports, the synovial tissues and skin lesions have the same T-cell clones, indicating that a common antigen drives T-cell immune response in the joints and skin lesions in  PsA patients. The IL-23/IL-17 axis plays an important pathogenic role for both PsA and Ps and biologics neutralizing IL-17A or IL-23/IL-12 are potent therapies. The different manifestations of the diseases may be explained with the help of differential expression of Th17 cytokines IL-17 and IL-22 at various sites. IL-17 is highly expressed in peripheral joints and skin lesions which leads to bone erosions. As for IL-22, it is highly expressed in skin lesions and entheses not peripheral joints and cause bone formation. Lastly, mannan from baker's yeast induced PsA-like arthritis and Ps-like skin lesions that were blocked by IL-17 treatment.

Therefore, it can be concluded that, PsA and Ps are likely to be the same disease revealing different manifestations depending on the local cytokine production.

Source:

Autoimmun Rev. 2017

Link to the source:

http://www.sciencedirect.com/science/article/pii/S1568997216302105

The original title of the article:

Are psoriasis and psoriatic arthritis the same disease?

Authors

Lazaros l. Sakkas, Dimitrios P. Bogdanos

SearchTags: 
Exploratory, Psoriasis, Psoriatic arthritis, Peripheral joints, Enthesis, Spine, Eyes
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