8% capsaicin cutaneous patch found effective in painful radiculopathies

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8% capsaicin cutaneous patch found effective in painful radiculopathies
Key Take-Away: 

Radiculopathy is a condition of pain, tingling, numbness, and weakness among the nerves of the spine, especially in the areas of lower back and neck. To counter this neuropathic pain, Capsaicin 8% patch is one of the best treatment, and this can be utterly observed through this study results.
 

The treatment of neuropathic pain caused due to low-back (lumbosacral) radiculopathies, is challenging and it often requires a multimodal therapeutic approach.

ABSTRACT: 
Background: 

The treatment of neuropathic pain caused due to low-back (lumbosacral) radiculopathies, is challenging and it often requires a multimodal therapeutic approach. The 8% capsaicin patch is the first topical analgesic approved for peripheral neuropathic pain.

To evaluate its efficacy, a subset of patients with painful radiculopathy (cervical and lumbar, including ventral and dorsal rami) enrolled into the multicenter, non-interventional QUEPP study (Qutenza2 – safety and effectiveness in peripheral neuropathic pain) were analysed.

Methods: 

Out of the 1044 study participants, 50 were diagnosed with painful radiculopathy as only peripheral neuropathic pain syndrome and were eligible for the evaluation. Patients received a single treatment (visit 1) and follow-up visits 2–5 at weeks 1–2, 4, 8 and 12.

Parameters assessed at all visits included pain intensity, neuropathy symptoms, and side effects. Quality of life (SF-12) and pain DETECT1 questionnaires were completed at baseline and final visit. Data were analyzed by monitoring the patch application site and duration of pain.

Results: 

Topical application led to a significant decrease in the pain intensity between weeks 1/2 and week 12 versus baseline at the application sites representing dermatomes of ventral (N = 26) and dorsal rami (N = 13) of spinal nerves.

A significant decline (p ≤ .001) of numeric pain rating scale scores was observed between weeks 1/2 following patch application and the end of observation (week 12) in the overall radiculopathy group (N = 50), and the groups with either 3 months to 2 years (N = 14) or >2 years (N = 23) duration of pain. Pain relief of at least 30% was observed in 50.0%, 71.4% and 39.1% of patients in the respective groups. Four patients experienced in total seven adverse drug reactions (application site pain or pruritus).

Conclusion: 

Effective neuropathic pain relief was observed after patch application within the innervation territories of both dorsal and ventral branches of the spinal nerve. Further controlled randomized trials are indicated.

 

Source:

Current Medical Research and Opinion

Link to the source:

http://www.tandfonline.com/doi/full/10.1080/03007995.2017.1322569?needAccess=true

Original title of the article:

Treatment of painful radiculopathies with capsaicin 8% cutaneous patch

Authors:

R.Baron et al.

Therapeutic, Capsaicin, Low-Back Radiculopathies, Nerves, Analgesia, Multicenter, Non-Interventional Study, Efficacy, Safety, SF-12, PainDETECT Questionnaires, Numeric Pain Rating Scale
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