25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis

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25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis

Joint pain and stiffness along with the panful inflammation is common among patients suffering from rheumatoid arthritis (RA). Quintana-Duque et al.conduced a study to distinguish the levels of 25-hydroxyvitamin D (25(OH)D) in patients with early-onset rheumatoid arthritis (EORA) versus a healthy control group. Also, to assess the association of 25(OH)D deficiency and the BsmI polymorphism of the vitamin D receptor gene with clinical, radiological, and laboratory parameters.

In this 3-year follow-up study, EORA Colombian patients were enrolled. Vitamin D deficiency was diagnosed for 25(OH)D levels of less than 20 ng/mL. To estimate data, Pearson and Spearman correlation coefficients were used.

The study comprised of 70 patients and all of them were healthy. The levels of 25(OH)D were reduced in the EORA group (27.13 [SD, 13.4] ng/mL vs. 33.74 [SD, 16.7] ng/mL; P=0.01); and 31.4% of EORA patients were vitamin D deficient. Remission was elevated in subjects without 25(OH)D deficiency (22.7% vs. 47.9%; P=0.04). After 3 years, patients with 25(OH)D deficiency at baseline had higher Health Assessment Questionnaire and Physician Global Disease Activity Assessment scores, fatigue levels, erythrocyte sedimentation rate, and morning stiffness. Only a relationship between 25(OH)D deficiency with fatigue and morning stiffness was found at the onset of the disease. Neither radiographic progression nor Sharp van der-Heidje score was was concerned with hypovitaminosis D after 36-month follow-up. In patients with vitamin D deficiency (0% vs. 16.6%; P=0.04), the bb genotype (similar alleles) was less frequent. Patients with BB-Bb genotype had lower 25(OH)D and a inclination to more severe disease.

It was thus found that the data further support for a role of vitamin D as a clinical biomarker for RA is needed. The baseline 25(OH)D could have potential as a predictor of disease severity in EORA.

Source:

JCR: Journal of Clinical Rheumatology

Link to the source:

http://journals.lww.com/jclinrheum/Abstract/2017/01000/The_Role_of_25_Hydroxyvitamin_D_as_a_Predictor_of.6.aspx

Original title of article:

The Role of 25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis

Authors:

 Quintana-Duque et al.

JCR: Journal of Clinical Rheumatology
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