“Official view” on glucocorticoids in rheumatoid arthritis based on international guidelines and consensus statements

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“Official view” on glucocorticoids in rheumatoid arthritis based on international guidelines and consensus statements

The understanding on the current role of systemic glucocorticoids (GC) in rheumatoid arthritis (RA)  management by examining their importance and the current level of evidence in recent guidelines is studied by Yannick Palmowski and colleagues through a systematic review. The open questions to be addressed in future guidelines and research projects were also recognised by the authors and are presented in the study.

Authors used PubMed, EMBASE and Cochrane databases to explore the systematic literature review for the guidelines on the pharmacological treatment of RA. The AGREE II tool was used to evaluate the relevant articles according to their quality and inspected for all relevant information regarding the use of GC.

All guidelines concur that GC, especially low doses for a short duration are suitable options in RA treatment. However, many recommendations remain indistinct as reliable and detailed evidence is limited. The significant elements of the GC therapy were partially or completely neglected, and the current nomenclature is not used consistently. Generally, quality estimation displayed flaws in many articles, regarding not only GC specific recommendations but also guideline quality.

Therefore, the current recommendations for the use of GC in the RA management are not satisfactory. Careful evaluation of dosages, timing and duration of their use was required. The existing nomenclature on GC therapy should be used consistently.

Source:

Arthritis Care & Research

Link to the source:

http://onlinelibrary.wiley.com/doi/10.1002/acr.23185/abstract

The original title of the article:

The “official view” on glucocorticoids in rheumatoid arthritis. A systematic review of international guidelines and consensus statements

Authors

Yannick Palmowski et al.

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