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Gout can be defined as an inflammatory arthritis that is caused by the deposition of mono-sodium urate crystals (MSU) in the synovial membrane, articular cartilage and periarticular tissues. It has been found to be more prevalent in men.

Revista brasileira de reumatologia
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Headache is defined as a pain arising from the head or upper neck of the body. The pain originates from the tissues and structures that surround skull or brain because the brain itself has no nerves that give rise to the sensation of pain (pain fibers).

Current Treatment Options in Neurology
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Cluster headaches occur as attacks of severe, one-sided headaches. Typically, a number of attacks occur over several weeks - about (cluster) of attacks. The headaches then usually go for weeks, months or years until a next cluster of headaches develops.

Cephalalgia
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A number of NSAIDs are recommended for the treatment of pain and inflammation associated with knee osteoarthritis. In this study, the investigators have been successful in evaluating the efficacy and safety of most common NSAIDs celecoxib or naproxen

Int J Rheum Dis. 2015 May 20
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Both gabapentin and pregabalin are generally used as first-line treatments for diabetic peripheral neuropathic pain, but mirogabalin has shown promise as a potential treatment for diabetic peripheral neuropathic pain.

Diabetes Care 2014;37:3253–3261
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Lidocaine is an amide type local anesthetic medication and its efficacy in post neuropathic pain (PHN) with irritable nociceptor phenotype still need to be explored. This study was a great success in estimating its efficacy in PHN patients with irritable nociceptor phenotype.

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Tofacitinib is used for the treatment of rheumatoid arthritis. Changes in serum creatinine levels with the administration of tofacitinib have created a need to fully understand the impact of tofacitinib on renal function.

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A particular treatment does not produce same results in two different subtypes of a disease. This study has perfectly compared the efficacy of sumatriptan in treating migraine with aura and without aura.

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Treatment for fibromyalgia may behave differently in different subgroups. In this study, the researchers have tried to assess the comparative effectiveness of treatments for fibromyalgia in adult subgroups.

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Medical interventions alone are not enough for management of tension type headache. In comparison to medical interventions, the multimodal manual therapy has emerged safe and effective way to provide relief in patients of tension type headache.

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