Vitamin D replacement therapy improves symptoms associated with musculoskeletal disorder

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Vitamin D replacement therapy improves symptoms associated with musculoskeletal disorder

Musculoskeletal disorders (MSDs) can be experienced by anyone as these are the injuries or pain commonly in the joints, ligaments, muscles, nerves, tendons, and structures that support limbs, neck and back. These are degenerative diseases and inflammatory conditions that induce pain and hamper day-to-day activities. Yilmaz R et al conducted this study to estimate the effects of vitamin D replacement therapy on musculoskeletal symptoms and overall quality of life in patients with chronic widespread musculoskeletal pain (CWP) involving fibromyalgia (FM) and vitamin D deficiency.

 The patients with nonspecific CWP and vitamin D deficiency (25-OH D3 < 25 ng/mL) were included in the study. For 3 months, replacement treatment of 50 000 IU/week oral vitamin D3 was given to the patients. Assessment of patients was done on the basis of pre- and post-treatments of serum levels of calcium, phospherous, alkaline phosphatase, 25-OH D3, severity of pain (visual analogue scale [VAS]-pain), severity of asthenia (VAS-asthenia), Beck Depression Inventory (BDI), quality of life scale (Short Form [SF]-36), tender point count (TPC), severity of waking unrefreshed, headache, tenderness on tibia, meeting the criteria of FM, and level of patient satisfaction.

A total of 58 patients with a mean age of 36.9±9.2 years were included in the study. The level of 25-OH D3 raised from 10.6±5.1 ng/mL to 46.5±24.0 ng/mL after replacement treatment (P<0.001). After treatment (P<0.001 ), marked decrease in VAS-pain, VAS-asthenia, severity of waking unrefreshed, TPC, and BDI and an evident increase in subgroups of SF-36 were initiated. Before treatment, the number of  FM+ patients was 30 (52%) and after treatment, it lapsed to 20 (34%). About 85% of patients revealed satisfaction with the treatment.

Thus, it can be concluded taht vitamin D replacement treatment in patients with nonspecific CWP has furnished improvements in musculoskeletal symptoms, level of depression and quality of life of patients. Patients with CWP should be scrutinized for vitamin D deficiency.


International journal of rheumatic disease

Link to the source:

Original title of article:

Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency


 Ramazan Yilmaz et al.

Therapeutic, Chronic widespread musculoskeletal pain (CWP), Fibromyalgia, Joints, Ligaments, Muscles, Nerves, Tendons, Chronic, VAS, VAS‐asthenia, Beck Depression Inventory (BDI), Short Form [SF]‐36), Tender point count (TPC)
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