Is there any association between use of short-acting benzodiazepines and migraine occurrence?

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Is there any association between use of short-acting benzodiazepines and migraine occurrence?

Migraines are painful with symptoms like a pounding headache, disturbed vision, nausea, vomiting and increased sensitivity to light and sound. This agonizing pain can last for hours or even several days. Harnod T, et. Al.,  performed a study to estimate the association between benzodiazepines (BZDs) with short- or long-acting durations and migraine occurrence.

Two groups were formed comprising of  9616 patients aged over 20 years and newly diagnosed with migraine between 2005 and 2011, and the other comparison group had 38,464 patients without migraine. The BZDs used in the patients were dichotomously explained as short-acting (half-life ≤24 h) and long-acting substances. To calculate the odds ratio (OR) of migraine associated with BZD exposure and other diseases, a logistic regression model was used. The adjusted OR of migraine concerned with BZD exposure was 1.73 (95% confidence interval [CI] = 1.63–1.84). Either exposure to a short-acting BZD alone or using it combining with a long-acting BZD had significantly higher risks of migraine (adjusted OR = 1.69, 95% CI = 1.59–1.80; adjusted OR = 2.06, 95% CI = 1.91–2.24, respectively). On the other hand, only long-acting BZD use was not concerned with an increase of migraine symptoms and association of migraine with sleep disorders, anxiety, and stroke (adjusted OR = 2.00, 1.91, and 1.57, respectively) was also observed.

A significant rise of migraine in patients using short-acting BZDs, either alone or in combination with long-acting ones was observed.


Current Medical research and opinion

Link to the source:

The original title of the article:

Association between use of short-acting benzodiazepines and migraine occurrence: a nationwide population-based case–control study


Tomor Harnod et al.

Exploratory, Benzodiazepines (BZDs), Migraine, Headache, Safety
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