Study findings: Vitamin D supplementation for knee osteoarthritis not reduce knee pain or slow cartilage loss
According to a study, "Vitamin D supplementation for individuals with knee osteoarthritis and low 25-hydroxyvitamin D levels did not reduce knee pain or slow cartilage loss." Symptomatic knee osteoarthritis has been found in 10% of men and 13% of women age 60 years or older.
Presently, there are no disease-modifying therapies for osteoarthritis. Vitamin D can reduce bone turnover and cartilage degradation, hence prevents the development and progression of knee osteoarthritis. As per studies, vitamin D supplementation is associated with benefits for knee osteoarthritis, but current evidence from clinical trials is contradictory.
A total of 413 patients with symptomatic knee osteoarthritis and low 25-hydroxyvitamin D were randomised to receive monthly treatment with oral vitamin D3 (50,000 IU; n = 209) or an identical placebo (n = 204) for 2 years by Changhai Ding, M.D., Ph.D., of the University of Tasmania, Hobart, Tasmania, Australia, and colleagues. Only 82% patients completed the study.
It was found that vitamin D supplementation which is compared with placebo, did not give significant result with no improvement in pain of knee over two years and no change in tibiofemoral bone marrow lesions were seen as well. However, there was increase in vitamin D levels were found in vitamin D group as compared to placebo group.
"These data suggest a lack of evidence to support vitamin D supplementation for slowing disease progression or structural change in knee osteoarthritis," the authors composed.