Short-term association between outdoor air pollution and osteoporotic hip fracture

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Short-term association between outdoor air pollution and osteoporotic hip fracture
Key Take-Away: 

Airborne pollutants are associated with various life-threatening health issues like breathing problems, lung, skin or respiratory diseases. However, whether the contaminants also show the impact on osteoporosis prognosis or not is not well known. The following study was therefore conducted to evaluate the influence these air pollutants on cases with hip fractures.

Introduction

The ecological retrospective cohort analysis aimed to determine the relationship of the levels of different airborne pollutants; SO2 and NO2 on the rate of osteoporotic hip fracture in a southern European region.

 

Methods

The data for the analysis was taken from three databases. The association between different outdoor air pollutants [monoxide (NO), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and particulate matter in suspension < 10-μm (PM10) and < 2.5 (PM2.5)] and hip fracture rates were identified in the time-series analysis using Poisson distribution. Crude and adjusted by different weather and seasons, the incidence rate ratio (IRR) was measured for all parameters. Hip incidence was later investigated by age (under or over age 75) and sex subgroups. The daily hospital admissions due to fracture were taken as the primary outcome measure of the analysis.

 

Results

Hip fracture rate exhibited the relationship with NO2 (IRR 1.02 (95% CI 1.01–1.04)), NO (IRR 1.01 (95% CI 1.01–1.02)), and SO2 (IRR 1.11 (95% CI 1.04–1.18)). This correlation was negative for O3 levels (IRR 0.97 (95% CI 0.95–0.99)). When the models were adjusted by season, the relationship endured for SO2 and NO2. Further, the association persisted for NO2 when models adjusted by season and weather conditions. The relationships maintained only in women older than 75 years when participants were stratified by age and sex.

 

Conclusions

A short-term relationship was noticed with various indicators of air pollution on hip fracture occurrence. This is the first investigation that explains these connections.

Source:

Osteoporosis International

Link to the source:

https://link.springer.com/article/10.1007%2Fs00198-018-4605-7

Original title of article:

Short-term association between outdoor air pollution and osteoporotic hip fracture

Authors:

R. Mazzucchelli et al.

Exploratory, Osteoporosis, Hip Bones, IRR
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