Serum Osteocalcin levels: Clinicians should track osteoporosis in gout patients

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Serum Osteocalcin levels: Clinicians should track osteoporosis in gout patients

A recently published study in Acta Clinica Belgica- International Journal of Clinical and Laboratory Medicine explained that the serum osteocalcin (OC) level plays a significant role in the estimation of bone turnover and the clinicians should be aware of osteoporosis in the gout patients.

Serum osteocalcin is the biochemical marker of the bone formation when the formation and resorption are uncoupled, and it is a valid marker of the bone turnover when the resorption and formation are coupled.

The risk of fracture is associated with osteoporosis, estimated by the Bone Mineral Density (BMD). BMD is known as a measure of the bone mass and an estimation of fracture. As the bone mass affects the bone strength or the ability to withstand trauma, about 90% of the variance in the bone strength is concerned with BMD.

Atalay Dogru and researchers performed this study to assess the relation of gout with osteoporosis and the serum osteocalcin (OC) levels. A total of 75 patients diagnosed with gout and 55 controls underwent the study. Comorbid conditions and drugs associated with osteoporosis were not considered. The dual-energy X-ray absorptiometry (DXA) was used to deduce the T and Z scores from the lumbar spine (L2–L4) and femur (neck, ward, trochanter, total). Enzyme-linked immunosorbent assay (ELISA) was used to measure the OC levels.

According to T scores of lumbar vertebrae L2–L4 osteoporosis was found to be higher in gout patients as compared to the control group. The lumbar spine T-score was −1.6 and −1.0 in the gout group and controls, respectively. The OC level was 7.9 ng/mL in the gout group and 18.9 ng/mL in the control group. Also, the mean OC level was 12.4 ± 6.9 ng/mL in the patients with osteoporosis and 17.2 ± 10.6 ng/mL in the patients that were portrayed as normal with a significant difference between the two groups (p = 0.03). A significant negative correlation was found between OC level and body mass index, age, and age at first attack. In the same way, femoral T-score displayed a negative correlation with parathyroid hormone, age, age at first attack, and allopurinol dose.


Acta Clin Belg. 

Link to the source

Original title of the article

Bone mineral density and serum osteocalcin levels in patients with gout.


Atalay Dogru et al.

Diagnostic, Osteoporosis, Bone, BMD, OC
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