The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults

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SCIENCE
The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults
Key Take-Away: 

A number of medicinal agents, including NSAIDs are used to treat and manage the pain associated with knee osteoarthritis. As compared to the side effects caused by diclofenac, a NSAID, the researchers have successfully dissected how and why enzyme, Wobenzyme is appropriate for long-term use in knee osteoarthritis pain.

This randomized, double-blind, placebo-controlled, and comparator-controlled trial evaluated the safety and efficacy of an enzyme combination, as Wobenzym, in adults with moderate-to-severe osteoarthritis (OA) of the knee.

ABSTRACT: 
Background: 

This randomized, double-blind, placebo-controlled, and comparator-controlled trial evaluated the safety and efficacy of an enzyme combination, as Wobenzym, in adults with moderate-to-severe osteoarthritis (OA) of the knee

Methods: 

Adults (n = 150) received Wobenzym, diclofenac (a nonsteroidal anti-inflammatory drug, NSAID), or placebo for 12 weeks. 

Results: 

Improvement in pain scores (Lequesne Functional Index) did not differ between subjects treated with Wobenzym or diclofenac, and both treatment groups improved compared to placebo (P< 0.05).

Reduction in total WOMAC scores (secondary outcome measure) did not differ between Wobenzym and diclofenac, although only diclofenac emerged as different from placebo (P< 0.05). The median number of rescue medication (paracetamol) tablets consumed was less in the Wobenzym group compared to placebo (P< 0.05), while there was no difference between diclofenac and placebo. Adverse events were similar in frequency in Wobenzym and placebo groups (7.2% and 9.1% of subjects, resp.) and higher in diclofenac group (15.6%).

Conclusion: 

Wobenzym is comparable to the NSAID diclofenac in relieving pain and increasing function in adults with moderate-to-severe painful knee OA and reduces reliance on analgesic medication.

Wobenzym is associated with fewer adverse events and therefore, may be appropriate for long-term use.

Arthritis 2015; 1-7
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