Ropivacaine found to be a Safe and Effective Method of Postoperative Analgesia

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Ropivacaine found to be a Safe and Effective Method of Postoperative Analgesia

A recently published randomised case study in the Journal of Anaesthesiology Clinical Pharmacology showed the caudal epidural injection of ropivacaine as an effective and safe approach in managing postoperative pain and opioid consumption lumbosacral spine surgery.

The caudal epidural technique is an underutilised approach among patients who went through lumbosacral spine surgery.
Navneh Samagh and colleagues conducted this study to evaluate the effect of pre-emptive analgesia, ropivacaine caudal epidural injection in reducing opioid consumption and pain after lumbosacral spine surgery. The study involved two groups; one was ropivacaine (R) group and second is saline (S) group with 40 patients each. In group R, for surgeries at or below L5 lumbar spine 20 ml of 0.2% ropivacaine caudal epidural injection was used and for surgeries from  L2 to L5 lumbar spine, 25 ml of 0.2% ropivacaine caudal epidural injection used. In group S, all received the same amount of saline. VAS was used to monitor anaesthesia efficacy immediately and at 4, 8, 12, and 24 hours after the treatment. The intraoperative fentanyl necessity and analgesia rescue time were also noticed.

Both groups exhibited similar hemodynamic variables, demographics and anaesthesia duration.  Group R showed significantly lower VAS scores, longer analgesia rescue time and meant intraoperative fentanyl need immediate after therapy  (P < 0.001) and at 4, 8, 12 and 24 postoperative hours (P =  < 0.001, 0.009, 0.007 and 0.046 respectively) as compared to group S.  Both groups exhibited neither neurological or hemodynamic side-effects.

All the study outcomes were in favour of the use of ropivacaine as the safe and effective method of postoperative analgesia.


Journal of Anaesthesiology Clinical Pharmacology       


The original title of article:

Pre-emptive caudal epidural analgesia with ropivacaine for lumbosacral spine surgery: A randomized case-control study


Navneh Samagh et al.

Therapeutic, Ropivacaine, Back Pain, Local Anesthesia, Randomized Case-Control Study, Efficacy, Safety, VAS.
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