Relation between uric acid, gout and kidney disease
The occurrence of gout and chronic kidney disease together has generated a curiosity to know the association between hyperuricemia (increase in uric acid level of the body) and kidney disease.
A recent issue of The Open Urology & Nephrology Journal, titled 'Current Perspectives in Hyperuricemia, Gout and the Kidney, has reported that many factors are involved in uric acid excretion but kidney play a major role and hyperuricemia is likely to be the reason for development of renal disease.
Chronic, low-grade, systemic inflammation is inherent to both conditions and this becomes an explanation against some mystifying observations noted in gout and kidney disease.
This thematic issue discusses the effect of the activation of the innate immune system, through stimulation of the NLRP3 inflammasome, leading to the subsequent generation of interleukins and the release of cytokines and chemokines, and how these factors interact in the complex interplay between hyperuricemia, gout and kidney disease.