A relation between migraine and serum magnesium levels

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A relation between migraine and serum magnesium levels

Migraine is a neurological disease, causing episodic attacks, which are different from common non-migraine headaches. Research shows that people with migraines often have low levels of magnesium. Also, because magnesium is needed for proper nerve function, it is thought that magnesium deficiency and migraines may be related. Recently, the role of magnesium in the treatment of migraine headache has been gaining scientific attention.

Magnesium is a mineral which is important for protein production, energy production, enzymes, normal muscle operation, bones strength, steady heart rhythm, healthy immune system and nerve function. Magnesium is the fourth most plentiful mineral in the human body. Half of body magnesium is in the bones and rest is inside cells. About 1% of magnesium is in the blood.

A study has shown that magnesium supplementation may reduce the frequency of migraine. To 50 migraineurs in addition to usual migraine medication, magnesium oxide pills were prescribed and placebo was administered to 50 healthy participants. At one and three months after intervention, results showed that in both groups, serum magnesium levels and headache severity was similar. Further, one month later after intervention, headache severity was similar. But, three months later, improvement in migraine symptoms and significant difference between two groups was found.

Thus, a magnesium deficiency resulting in low levels of magnesium in the brain causes the brain to become irritated and may trigger migraine attacks. In conclusion, clinical findings showed that magnesium supplementation can reduce the frequency of migraine headaches and is a new therapeutic way for prevention and treatment of migraine.

J App Pharm Sci.
Therapeutic, Magnesium, Migraine, Headache, Nerve, Minerals, Acute
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