Regulation of urate in the human body
Gouty arthritis is one of the most frequent painful medical disorders. The inflammation and intense pain in the gouty condition is caused by the accumulation of the urate crystals in the affected joint. High levels of uric acid in the blood can lead to the formation of the urtate crystals. The chief cause of the gout is the elevated serum urate concentration. Urate is usually produced during the metabolism of endogenous (DNA and RNA) and exogenous (food-derived) purines. Once produced, urate cannot be further metabolized by human body cells. Thus, they must be eliminated by either renal or extra-renal elimination routes, that is; primarily via the intestine and the intestinal flora.
The uric-acid-lowering medications are the central treatment for gout. To understand the etiology and treatment of gout, the processes that affect the serum urate concentration is highly important. Thus, the three principle processes for this condition are: production, renal elimination, and intestinal elimination. A variation in any of these processes can affect steady-state serum urate concentration as well as other urate processes. Urate is just a waste product to be eliminated out of the body but it plays a pivotal role in understanding the process and management of gouty conditions.