Propofol: An effective analgesic for postoperative pain

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Propofol: An effective analgesic for postoperative pain

Formerly, the doctors believed that the post-amputation phenomenon was a psychological problem, but experts now admit that these real sensations arise in the spinal cord and brain. When the pain is felt from a body part that's no longer there, it is known as the phantom pain.

Application of propofol is both for induction and maintenance of anesthesia. Current studies depict that propofol has analgesic characteristics. This systematic review and a meta-analysis portrayed differences in postoperative analgesia between general anesthetic maintenance with intravenous propofol and inhalational anesthetics. About fourteen trials met inclusion criteria and were inculcated. The outcomes obtained were 2 and 24 h after surgery. No remarkable difference in pain scores was revealed at 2 h after surgery (Hedge's g (95% CI) −0.120 (−0.415–0.175) (p = 0.425). Propofol was concerned with a statistically significant, albeit marginal, reduction in pain scores 24 h after surgery (Hedge's g (95% CI) −0.134 (−0.248 to −0.021) (p = 0.021). Inspite of 24-h morphine-equivalent consumption, the data was inadequate to allow a meaningful analysis. Propofol was related with reduced postoperative nausea and vomiting (relative risk (95%CI) 0.446 (0.304–0.656) (p < 0.0001).

Thus, final analysis of this study predict that propofol boosts postoperative analgesia compared with inhalational anesthesia 24 h after surgery, with a lower incidence of nausea and vomiting.

Anesthesia & Analgesia
Exploratory, Propofol, Postoperative pain, Acute, General anaesthesia, Analgesia, Systematic review, Meta-analysis, Intravenous, Inhalation.
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