Patients with Destructive Hand Osteoarthritis have Lower Serum Clusterin Levels

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Patients with Destructive Hand Osteoarthritis have Lower Serum Clusterin Levels

The journal of BMC Musculoskeletal Disorders presents a study, which highlights that erosive hand osteoarthritis (OA), have lesser concentrations of clusterin (CLU).

The CLU is an apolipoprotein J protein, involved in various biological activities like apoptosis and inflammation. Tereza Kropáčková and colleagues, the researchers of the study conducted this analysis to compare CLU serum levels among healthy and hand OA patients and destructive and non-destructive disease condition. A relationship of CLU concentrations with laboratory and clinical parameters was also assessed.

The analysis comprised 135 hand OA patients and 53 healthy people. Out of 135 hands OA patients, 81 suffered from destructive and 54 from non-destructive disease condition. All healthy and OA individuals went through hand joint ultrasound and clinical examination. The pain was determined via visual analogue scale (VAS), algofunctional index and Australian/Canadian hand osteoarthritis index (AUSCAN). ELISA (enzyme-linked immunosorbent assay) was used to measure CLU serum levels.

The hand OA patients and patients with destructive form exhibited a considerably lower level of CLU levels as compared to healthy (p < 0.0001) and non-destructive patients group (p = 0.044) respectively. The VAS and AUSCAN scores showed a negative associated with CLU levels (p = 0.049; 0.013, respectively). The outcomes reflect that patients with destructive hand OA condition show a negative association with CLU levels.


BMC Musculoskelet Disord             


The original title of article:

Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain


Tereza Kropáčková et al.

Exploratory, Hand Osteoarthritis, Hand Joints, VAS, AUSCAN, Algofunctional Index, ELISA
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