Paracetamol is Ineffective at Any Dose Against Osteoarthritis

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Paracetamol is Ineffective at Any Dose Against Osteoarthritis

A new study revealed that paracetamol, a common over-the-counter pain killer is not effective for osteoarthritis treatment. Broad survey of 74 clinical trials including nearly 60,000 patients showed that paracetamol is insignificant and slightly effective to ease the pain but better than a placebo.

Sven Trelle, the main architect of the meta-study and a researcher at the University of Bern in Switzerland said "Our results suggest that paracetamol at any dose is not effective in managing pain in osteoarthritis". Sven and co-workers assessed eight different NSAIDs which were given to patients individually with varying doses and also in combination with other medications. Out of these eight, diclofenac found to be best. Owing to this, diclofenac sold out in many countries under the brand names Voltaren, Aclonac and Cataflam. All these results were published in the medical journal "The Lancet".

Osteoarthritis is one of the most prevalent joint disease causing acute stiffness and pain which takes place due to breakdown of protective cartilage on bones ends. Osteoarthritis is most common in people older than 60, it distress about 9.5% of men and 18% of women. This disease can affect any joint, but it occurs most often in knees, hands, hips and spine. However, osteoarthritis has no cure and it get worsens bit by bit. "This finding is not entirely unexpected," noted Nicholas Moore and three colleagues from the department of pharmacology at the University of Bordeaux in southwestern France.

"Paracetamol has been on the market for as long as most of us remember. It efficacy has never been properly established or quantified in chronic diseases," they wrote in a comment, also published in The Lancet.

Therapeutic, Paracetamol, Osteoarthritis, Hands, Spine, Knees, Hips, NSAIDs, Meta-analysis
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