Oral Prednisolone: A better option for reducing swelling in patients with gout
A new research conducted at the Department of Endocrinology of Nanfang Hospital affiliated to Southern Medical University between April 2015 and August 2015, depicted that prednisolone might be more effective in reducing swelling of joints as compared to indomethacin over 4 days of treatment.
Acute gout is an intensely painful inflammatory arthritis. It is a disease caused by the accumulation of uric acid crystals in a joint. Pain is usually the first symptom of gout for most of the people. Initially, only single joint is affected but if it is left untreated, other joints may also get affected. In current scenario, different types of medications are available for the treatment of acute gout arthritis (AGA) but whether the treatment has really benifitted the patient, is a matter of utmost importance. In this context, randomized parallel controlled study was conducted to compare the safety, tolerability and efficacy of prednisolone, etoricoxib and indomethacin for acute gout arthritis. Patients were administered prednisolone 35 mg qd, etoricoxib 120 mg qd, or indomethacin 50 mg tid.
Data was evaluated from 113 AGA patients for the efficacy and safety of prednisolone, etoricoxib, and indomethacin. After analyzing the data, it was found that the improvement in pain, tenderness and joint activity was noticed after the four days of treatment. During the study, more adverse events were reported with indomethacin than prednisolone and etoricoxib.
This controlled trial showed that oral prednisolone, a corticosteroid, was more effective in reducing swelling and inflammation than indomethacin. These results may suggest prednisolone as a promising option for reducing swelling in patients with gouty arthritis however the choice of treatment may depend on each patient’s condition and comorbidities.