Mortality rates and predictors in people with recent onset of gout

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Mortality rates and predictors in people with recent onset of gout

Gout or Gouty arthritis refers to an onset of sudden burning pain, stiffness, and swelling in a joint, mostly big toe joint. This present study aims to find the mortality rates and predictors of death at baseline in people with a recent onset of gout.

The study included people suffering from gout for duration < 10 years. The comprehensive clinical assessment was completed at baseline. The participants were prospectively followed for at least 1 year. Information about death was systematically collected from primary and secondary healthcare centers. Cox proportional hazard regression models were used to calculate standardized mortality ratios (SMR) and risk factors for mortality.

As per the study, the mean (SD) followup duration was 5.1 (1.6) years (a total 1511 patient-yrs accrued). Out of total 295 participants, 43 (14.6%) had died at the time of censorship (SMR 1.96, 95% CI 1.44–2.62). In the reduced Cox proportional hazards model, these factors were independently concerned with an increased risk of death from all causesincluding older age (70–80 yrs: HR 9.96, 95% CI 3.30–30.03; 80–91 yrs: HR 9.39, 95% CI 2.68–32.89), Māori or Pacific ethnicity (HR 2.48, 95% CI 1.17–5.29), loop diuretic use (HR 3.99, 95% CI 2.15–7.40), serum creatinine (per 10 μmol/L change; HR 1.04, 95% CI 1.00–1.07), and the presence of subcutaneous tophi (HR 2.85, 95% CI 1.49-5.44). The presence of subcutaneous tophi was the only baseline variable independently related with both cardiovascular (CV) cause of death (HR 3.13, 95% CI 1.38–7.10) and non-CV cause of death (HR 3.48, 95% CI 1.25–9.63).

Therefore, it can be culminated that the people with gout for <10 years have an increased risk of death. For both CV and non-CV causes, the presence of subcutaneous tophi at baseline is an independent predictor of mortality.


J Rheumatol.

Link to the source:

Original title of article:

Predictors of Mortality in People with Recent-onset Gout: A Prospective Observational Study


Zoë L. Vincent et al.

J Rheumatol.
Diagnostic, Gout, Joints, Prospective Observational Study, SMR
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