Intravenous caffeine citrate and magnesium sulfate found to be efective acute migraine headache

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Intravenous caffeine citrate and magnesium sulfate found to be efective acute migraine headache

A migraine is characterised by attacks of throbbing, unilateral pain associated with nausea, vomiting, phonophobia, and photophobia. The evidence demonstrates that intravenous magnesium sulfate might be useful in reducing pain in migraine. In a recent pilot study, it was shown that intravenous caffeine citrate could lessen the severity of a migraine headache.

This research aims to investigate the efficacy of intravenous caffeine citrate vs magnesium sulfate for the management of an acute migraine headache. The study conducted a prospective quasi-experimental survey in two academic, medical centres of Shahid Beheshti University of Medical Sciences (Shoahadaye Tajrish Hospital and Imam Hossein Hospital), Tehran, Iran from January until May 2016. The quasi-experimental study involved patients who were referred to the emergency department and met the migraine diagnosis criteria of the International Headache Society. Patients were assigned to 2 grouping sustain in general 2 g intravenous magnesium sulfate and 60 mg intravenous caffeine. The pain scores, found on the visual analog scale, were noted on admission, as well as one and two hours after sustaining the drug. To analyse the baseline characteristics Chi-Square test and student t-test were used. A Mann-Whitney U test and Wilcoxon signed-rank test were used to analyze differences in the visual analog scale (VAS) score between and within the section consequently. A total of 70 patients (35 patients in each section) with the mean age of 33.1 ± 11.3 years were involved 64.3% women. For the Caffeine citrate group, the median pain score reduces from 9.0 (2.0) to 5.0 (4.0) after 1 hour and to 3.0 (4.0) after 2 hours. The pain scores for the magnesium sulfate group lessened from 8.0 (2.0) to 2.0 (2.0) after 1 hour and to 0.0 (1.0) after 2 hours.

Both intravenous caffeine citrate and intravenous magnesium sulfate diminished pain scores remarkably, but the magnesium sulfate group exhibit more enhancement than the Caffeine citrate group after one hour (P < 0.001) and after two hours (P < 0.001). It is probable that both intravenous caffeine and intravenous magnesium sulfate can reduce the severity of a migraine headache. Also, intravenous magnesium sulfate at a dose of 2 g might be superior to intravenous caffeine citrate 60 mg for the short-term management of a migraine headache in emergency departments.


Korean J Pain. 2017 Jul;30(3):176-182.

Link to the source:

Original title of the article:

Intravenous caffeine citrate vs. magnesium sulfate for reducing pain in patients with acute migraine headache; a prospective quasi-experimental study.


Alireza; B. et al.


Therapeutic, Caffeine citrate, Magnesium sulfate, Migraine, Acute, Efficacy, VAS, Intravenous
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