Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery

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Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery

According to a multicenter 2 × 2 factorial randomized, placebo-controlled pilot trial results published in The Journal of Pain the more extensive clinical trials can be conducted to further validate the positive effects of intraoperative Lidocaine infusions for the persistent postoperative neuropathic pain associated with breast cancer surgery.

Persistent postoperative pain is confined to the region of surgery of a span of ≥2 months and is, regrettably, a frequent complication following breast cancer surgery. However, very less investigation has been carried out for its management so far. As per previous reports, intravenous Lidocaine and perioperative Pregabalin exhibited positive effects on persistent postoperative pain.

A total of 100 female participants experiencing breast cancer surgery were selected and obtained a 1.5mg/kg bolus succeeded by 2 mg/kg/h intraoperative Lidocaine infusion or placebo and 300mg preoperatively, 75mg twice daily for nine days perioperative Pregabalin or placebo. The achievement of follow-up target was accomplished at three months with a 100% follow-up rate. Fifty-three per cent of the participants mentioned persistent neuropathic pain at three months. No interaction was noticed between the Pregabalin and Lidocaine. Lidocaine reduced persistent neuropathic pain progress. No reduction in persistent pain was noticed among patients who received Pregabalin. No impact was observed on the pain interference, acute postoperative pain, quality of life, and opioid consumption with either Lidocaine and Pregabalin. This trial provides promising information regarding intraoperative Lidocaine that warrants further investigation, on its effectiveness and tolerability in the perioperative setting.

Source:

The Journal of Pain

Link:

https://www.jpain.org/article/S1526-5900(18)30519-4/fulltext

Original title of article

Perioperative Pregabalin and Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery: A Multicenter, Factorial, Randomized, Controlled Pilot Trial

Authors:

James S. Khan et al.

SearchTags: 
Therapeutic, Pregabalin, Lidocaine, Neuropathic Pain, Nerves, Anticonvulsant, Local Anesthesia, Multicenter, Factorial, Randomized, Controlled Pilot Trial, Intravenous, Oral
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