Increasing prevalence of cortical porosity in women with hip fracture

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Increasing prevalence of cortical porosity in women with hip fracture

The hip fractures lead to high mortality rate and disability and consume significant healthcare resources.

As per the dual-energy X-ray absorptiometry (DXA) measurement, only 46% of hip fracture patients have osteoporosis at the total hip. With age, the cortical porosity increases which are assumed crucial for bone strength. The higher cortical porosity than the controls and whether this difference is independent of clinical risk factors and areal bone mineral density (aBMD) was assessed in this study.

In this ongoing population-based study, 46 women with a prevalent X-ray-verified hip fracture and 361 control subjects without any fractures were recognized and DXA was used to calculate the aBMD. To find the bone microstructure at the standard (ultradistal) site and at 14% (distal) of the tibial length, high-resolution peripheral quantitative computed tomography was used.

The results showed that women with a previous hip fracture had lower aBMD at the femoral neck (11.8%) and total hip (-14.6%) plus higher cortical porosity at the ultradistal (32.1%) and distal (29.3%) tibia as compared to controls. The covariates (age, height, weight, smoking, calcium intake, physical activity, walk time, oral glucocorticoids, parental hip fracture, rheumatoid arthritis, previous fall, current bisphosphonate treatment and femoral neck aBMD) in the multivariable logistic regression analysis revealed cortical porosity at the ultradistal [odds ratio; OR per standard deviation; SD escalate (95% confidence interval; CI) 2.61 (1.77-3.85)] and distal [1.57 (1.12-2.20)] sites concerned the prevalent hip fracture.

Hence, the cortical porosity was concerned with the prevalent hip fracture in older women independent of femoral neck aBMD and clinical risk aspects.


Journal of internal medicine

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The original title of the article:

Increased cortical porosity in women with hip fracture


Sundh D et. al

Exploratory, Fractures, Hip, Population-based Study, DXA
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