Imaging Photoplethysmography to Disclose Capsaicin-Induced Parameters of Microcirculation in Migraine Patients

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Imaging Photoplethysmography to Disclose Capsaicin-Induced Parameters of Microcirculation in Migraine Patients

A recent study published in 'The Journal of Headache and Pain' explained the usefulness of Blood pulsation amplitude (BPA) dynamics evaluated by imaging photoplethysmography. This could serve as a promising sensitive non-invasive biomarker of migraine-associated modifications in microcirculation.

To fabricate a personalized medication for migraine, the non-invasive biomarkers can be helpful. It has already been established that the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons is related to the release of the migraine mediator CGRP in the testing of the antimigraine drugs.

A total of 28 patients- 14 migraine patients (mean age 34.6 ± 10.2 years) and 14 healthy volunteers (mean age 29.9 ± 9.7 years) took part in the experiment. Recently, a new arrangement of imaging photoplethysmography was developed by Alexei A. Kamshilin and researchers which was used in this experiment. It was used to discover novel sensitive parameters of dermal blood flow during capsaicin applications in migraine patients.

Blood pulsation amplitude (BPA) was observed as an optical-intensity waveform which varied synchronously with heartbeat. It was used for detailed exploration of microcirculatory perfusion instigated by Capsicum patch application. The BPA signals, once having appeared after a certain latent period, continuously ascended until being saturated. "Hot-spots" arose as a result of Capsaicin-induced high BPA areas which were distributed roughly under the patch.  Intriguingly,  the hot spots were much more inconsistent in migraine patients than in the control group. As opposed to BPA, a slow component of waveforms concerned to the skin redness altered significantly less than BPA. It was proved that BPA is a promising sensitive biomarker of capsaicin-induced activation of the blood flow. Hence, there is a non-uniform (both in space and in time) reaction to Capsaicin, producing highly variable openings of skin capillaries in the migraine patients. 


The Journal of Headache and Pain

Link to the source:

Original title of the article:

Novel capsaicin-induced parameters of microcirculation in migraine patients revealed by imaging photoplethysmography


Alexei A. Kamshilin et al.

Diagnostic, Capsaicin, Migraine, Head, Alkylamide, Analgesic
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