How Pregabalin Improves Neuropathic Pain

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How Pregabalin Improves Neuropathic Pain

Neuropathic pain is a pain that comes from problems with signals from the nerves. This pain is different to the common type of pain that is due to an injury, burn or pressure. According to a study published in Pain Practice, Pregabalin significantly improves pain, irrespective of the time since onset of neuropathic pain.

Concepcion Perez, PhD, from the Hospital de la Princesa in Madrid, Spain and colleagues carried out a pooled analysis of 19 randomized placebo-controlled trials of pregabalin for peripheral neuropathic pain conditions such as diabetic peripheral neuropathy, post herpetic neuralgia, and post-traumatic/postsurgical pain). Researchers divided the patients into 5 groups according to time since onset of pain (< 6 months, 6 months to < 1 year, 1 year to < 2 years, 2 years to < 5 years, and ≥ 5 years). For each group, the mean change in pain score at end point was assessed versus placebo. Analysis were included for 5,783 patients (3,619 pregabalin and 2,164 placebo).

The researchers revealed that across pain duration groups, the mean baseline pain scores were similar. Pregabalin significantly improved pain score at end point vs placebo (treatment difference, −0.59); similar results were seen in each pain duration group. Significantly more Patient Global Impression of Change responders were seen with pregabalin vs placebo for all patients (45 vs 30.9%) and for each group separately. However, no significant and consistent differences in treatment response were noticed between the different groups of pain duration.

Pain Practice
Exploratory, Pregabalin, Neuropathic pain, Pooled analysis
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