High animal protein intake lowers the risk of osteoporotic fracture in older men

Primary tabs

High animal protein intake lowers the risk of osteoporotic fracture in older men

Dietary protein is a potential modifiable risk factor for the occurence of fractures. The present study aimed to probe out the association between protein intake and the incident fracture among older men and whether these associations diversified by protein source or by skeletal site. A logitudinal cohort of 5875 men (mean age 73.6, SD = 5.9 years) in the Osteoporotic Fractures in Men (MrOS) study was considered for the better understanding of the objective of this study. At the baseline, protein intake was analyzed as a percent of total energy intake (TEI) with mean intake from all sources=16.1% TEI.

By the physician review of medical records, incident clinical fractures were established.

During 15 years of follow-up, 612 major osteoporotic fractures, 806 low-trauma fractures, 270 hip fractures, 193 spine fractures, and 919 non-hip non-spine fractures were detected. The  Cox proportional hazards models with age, smoking,  race, height, clinical site, TEI, physical activity, marital status, osteoporosis, gastrointestinal surgery, oral corticosteroids use, alcohol consumption, and calcium and vitamin D supplements as covariates to calculate hazard ratios (HR) with 95% CI, all demostrated per unit (SD=2.9% TEI) increase was used. Higher protein intake was associated with a reduced risk of major osteoporotic fracture (HR=0.92 [95% CI: 0.84, 1.00]) and a similar association found for low-trauma fracture. The relation between protein and fracture varied by protein source. Increased dairy protein and non-dairy animal protein were associated with a decreased risk of hip fracture (HR = 0.80 [95% CI: 0.65, 0.98] and HR = 0.84 [95% CI: 0.72, 0.97], respectively). But this was not the case with plant-source protein (HR = 0.99 [95% CI: 0.78, 1.24]). The association between protein and fracture assorted by fracture site; total protein was associated with a decreased risk of hip fracture (HR = 0.84 [95% CI: 0.73, 0.95]), but not clinical spine fracture (HR = 1.06 [95% CI: 0.92, 1.22]).

It was thus culminated that those with high protein intake (specially high animal protein intake) as a percentage of TEI have a lower risk of major osteoporotic fractures.


J Bone Miner Res.

Link to the source:


Original title of article:

The Association Between Protein Intake by Source and Osteoporotic Fracture in Older Men: A Prospective Cohort Study


 Lisa Langsetmo et al.

J Bone Miner Res.
Exploratory, Osteoporosis, Bones, Prospective Cohort Study, Hazard ratios (HR)
Log in or register to post comments