Distinct Comorbidity Conditions Cluster in Patients with Gout

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Distinct Comorbidity Conditions Cluster in Patients with Gout

According to the latest research study published in the 'Rheumatology' journal, the gout patients with multiple comorbidities were more likely to receive allopurinol. Also, the study has emphasized the importance of tailoring the treatments based on cluster and comorbidities. 

Megan Bevis et al. investigated that how comorbid conditions cluster in patients with gout in a UK primary care population. This cross-sectional study used baseline data from a primary-care based prospective observational cohort of people aged ⩾18 years with gout. The primary care medical records were used to recognize the participants suffering from gout. Factor analysis was done to reveal the evident clusters of comorbidity variables comprising obesity, hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease, heart failure, chronic kidney disease (CKD) and cancer. The hierarchical cluster analysis of patient observations was helpful in distinguishing the homogenous subgroups of patients based on combinations of their comorbidities.

A total of 1079 participants with the mean age (S.D.) of 65.5 years (12.5) participated in the study. Four different comorbidity clusters (C1–C4) were recognized. Cluster C1 (n = 197, 18%) was the oldest group with patients with the most repeated attacks of gout; 97% had CKD.  In the C2 (n = 393, 36%), isolated gout with few comorbidities was observed in participants.  Hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease and/or CKD were common in the cluster C3 (n = 296, 27%) with urate-lowering therapy prescription more persistently than in other clusters. The patients in the C4 (193, 18%) had hypertension and were more likely to be obese than other clusters. Overall, this study established four distinct comorbidity clusters in gout patients.



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The original title of the article

Comorbidity clusters in people with gout: an observational cohort study with linked medical record review


Megan Bevis et al.

Exploratory, Allopurinol, Gout, Joints, Chronic, Xanthine oxidase inhibitors, Observational cohort study, Factor analysis, Hierarchical cluster analysis
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