Corticosteroid transdermal delivery can improve arthritis pain and functional disability

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Corticosteroid transdermal delivery can improve arthritis pain and functional disability

Almost everyone, at some point in their life period, feels pain and stiffness in their joints which might be associated with arthritis. Arthritis and associated symptoms can affect patient’s quality of life to a great extent. Therefore, certain therapeutic strategies are applied to overcome this concern which often includes steroids and its classes like corticosteroids.

Recently, a study evaluated the efficiency of betamethasone valerate (a corticosteroid), medicated plaster in improving the arthritis patient's condition using transdermal delivery, one of the best drug delivery strategy.

For the study, 104 patients were enrolled affected by osteoarthritis (OA) (n = 40) or arthritis (n = 64) in different joints. The patients were divided into two groups, one received betasil (2.25mg, once before bedtime) and other received diclofenac sodium cream (2g, four times a day) for 10 days to study comparable effects. Later, techniques like visual analogue scale (VAS) and Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) were used to measure pain and functional disability. Furthermore, “fovea sign” method was used to measure edema and C-reactive protein (CRP) for monitor the pharmacological treatment efficiency. A clinical inspection was also done to determine the redness of the skin.

The results were assessed at two points, one at the baseline and another at 10-day follow-up. The VAS and WOMAC results showed better improvement in Betesil's group than diclofenac (all p < 0.01) at 10-day follow up. Further, the CRP levels and “fovea sign” method scores were also greater in case of Betesil's group than diclofenac (all p < 0.01).

Overall, the whole study determined that transdermal delivery of betamethasone valerate is very effective and safe for patients with arthritis and OA.


Drug Deliv Transl Res. 2017 Feb;7(1):156-161

Link to the source:

The original title of the article:

Corticosteroid transdermal delivery significantly improves arthritis pain and functional disability


Tommaso lannitti; Micheal F. McDermott et al.

Therapeutic, Arthritis, Joints, Betamethasone valerate, Corticosteroid, Efficacy, VAS, WOMAC, Transdermal
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