Cartilage repair in osteoarthritis by mesenchymal stromal cells
Treatment of articular cartilage injury poses a great challenge to the researchers because there is a limited scope of repair and restoration after the damage. The conventional treatments are not very effective in restoring the normal function of the joints affected. Therefore, it has become mandatory for the researchers to explore the new and effective approaches for the treatment of osteoarthritis.
The current era of regenerative medicine mainly emphasizes on cell based therapies, which may allow us to explore and achieve the restoration of injured or affected joint.
A group of investigators conducted a review study to define the advancement and growth of employing mesenchymal stromal cell (MSC)-based therapy as an effective substitute for OA treatment. The prime most objective of the study was to put light on how in vitro MSC chondrogenic differentiation stimulates in vivo embryonic cartilage development and to define numerous chondrogenic differentiation strategies followed by pre-clinical and clinical studies representing their possibility and effectiveness. Before this research can be transferred to the clinics, the utmost requirement is to tackle many challenges.
There is a need to understand the post-transplanted cell behavior and learning to augment their strength in the disease microenvironment. The only motive is to highlight the prominence of isolation, storage, cell shipment, route of administration, optimum dosage and control batch to batch variations to recognize the full potential of MSCs in OA clinical trials.